0-9
A B C D E F G H I J K L M N O
P Q R S T U V W X Y Z
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found

BRCAvantage™, Single Site

Test code(s) 91865

Question 1. To whom should this test be offered?

Consider offering this test to men and women with a family history of a known mutation in the BRCA1 or BRCA2 gene. Official test results of the family member must be available for laboratory review. For more information or to discuss a family history with a Quest Diagnostics genetic counselor, please call Quest Genomics Client Services at 866-GENE-INFO.

Question 2. Is there a better test for my patient?

When BRCA-related breast and/or ovarian cancer syndrome is suspected and no BRCA1 or BRCA2 mutation testing has been performed, consider ordering the BRCAvantage®, Comprehensive test (test code 91863).

Additional tests are available to assess the risk of hereditary cancer. Please refer to the BRCAvantage® Plus™Test Menu FAQ for a description of test codes, or refer to the Hereditary Cancer Test Selection Guide. For more information or to discuss a family history with a Quest Diagnostics genetic counselor, please call Quest Genomics Client Services at 866-GENE-INFO.

The National Comprehensive Cancer Network (NCCN) has guidelines forBRCA1 and BRCA2 mutation testing (http://www.nccn.org). The guidelines strongly recommend genetic counseling for the patient before ordering this test. Generally, individuals with a personal diagnosis of early onset (≤50 years) breast cancer, bilateral breast cancer, and/or ovarian cancer and/or a strong family history of breast and/or ovarian cancer are appropriate for BRCAvantage ®, Comprehensive testing. The person in the family with the strongest indication of hereditary cancer, such as the person with the earliest diagnosis of breast and/or ovarian cancer, should be tested first whenever possible.

For more information or to discuss a family history with a Quest Diagnostics genetic counselor, please call Quest Genomics Client Services at 866-GENE-INFO.

Question3. My patient has a positive result. What does this mean?

If your patient tests positive for a pathogenic or likely pathogenic BRCA1 or BRCA2 mutation, he/she is at significantly increased risk for developing breast and ovarian cancer and other related cancers compared to the general population.

NCCN provides up-to-date surveillance and management recommendations for mutation carriers (http://www.nccn.org). Referral to an oncology center experienced in treating patients with a BRCA1 or BRCA2 mutation might be considered to discuss options. These options include increased surveillance, chemoprevention, and prophylactic surgery.

Question 4. My patient has a negative result. What does this mean?

1.     Patient previously diagnosed with breast or ovarian cancer

The familial mutation was not found. Your patient’s risk of recurrence or a related new cancer is based on his/her personal history of cancer. In some instances, it may be appropriate to test for other BRCA1 or BRCA2 mutations or hereditary forms of cancer. Family history of cancers not related to BRCA mutations should be considered. Please call Quest Genomics Client Services at 866-GENE-INFO to discuss possible additional studies with a genetic counselor.

2.     Patient not previously diagnosed with breast or ovarian cancer, but with a family history of breast and/or ovarian cancer

The familial mutation was not found. Your patient’s risk of recurrence is based on his/her personal and family histories of cancer. In some instances, it may be appropriate to test for other hereditary forms of cancer. Family history of cancers not related to BRCA mutations should be considered. Please call Quest Genomics Client Services at 866-GENE-INFO to discuss possible additional studies with a genetic counselor.

Reference

  1. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Genetic/familial high-risk assessment: breast and ovarian. V2.2016. Rockledge, PA: National Comprehensive Cancer Network, 2016. Available online with free registration.
This FAQ is provided for informational purposes only and is not intended as medical advice. A physician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.
Document FAQS.123 Version: 2