Education Center

0-9
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found
  • No FAQs found

Yes
No

HCV Genotyping
Test code(s) 37811X


Question 1. The HCV genotype test result is “we were unable to obtain an HCV genotype,” but the patient has a detectable viral load. Why was there no genotype result?

The LiPA genotype assay usually requires a minimum viral load of 300 IU/mL to obtain a genotype. Since many of our viral load assays have a much lower limit of quantitation, it is possible for the patient to have a detectable viral load (below 300 IU/mL) and no genotype result.

Question 2. The test result is "1a" with a comment stating "we cannot rule out 6 subtypes c-I." Does that mean the patient is coinfected?

Not necessarily. The HCV genotyping assay is performed by analyzing banding patterns that are indicative of the genotype. Two regions of the genome are assessed: the 5' UTR and the core region. Genotype 6 subtypes c-l have the same banding pattern as genotype 1. Therefore, the core region is used to elucidate a type 1 from a type 6. If the core region banding pattern is not conclusive, we report a type 1 but cannot rule out type 6 subtypes c-l.

This FAQ is provided for informational purposes only and is not intended as medical advice. A physician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.
Document: FAQS.21 Revision: 0