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Argatroban

Test code(s) 90413

This is an outdated version of this FAQ. It was effective 05/30/2012 to 01/10/2016.

The current version is available here.

Question 1. What is the methodology used for the argatroban assay?

The method used is a dilute thrombin clotting time method (functional assay).

The clotting time is directly related to the concentration of argatroban in the sample. The clotting time in the patient sample is compared to that of calibrators. Calibrator concentration (mcg/mL) has been verified using liquid chromatography tandem mass spectrometry (LC/MS/MS). Patient results are reported in mcg/mL.

Question 2. What is the reportable range of this assay?

The analytical measurement range (AMR) of the assay is 0.16 to 1.95 mcg/mL. After sample dilution, concentrations up to 3.00 mcg/mL can be reported.

Question 3. When are steady-state levels of argatroban typically attained?

Steady-state is typically attained within one to three hours. Recommend blood collection during this time interval since the elimination half life of argatroban ranges between 39 and 51 minutes.1

Reference

  1. Argatroban [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2012.
This FAQ is provided for informational purposes only and is not intended as medical advice. A physician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.

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