Expert Insights Newsletter by Author

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Reducing Cardiac Risk in Patients with Elevated Triglycerides

The primary objective in managing patients with high triglycerides is to reduce long-term cardiac risk. Dr. Douglas Jacoby, Director, Penn Cardiology Preventative Care discusses the importance of identifying metabolic syndrome in these patients and the role of advanced testing to... Read more 

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BRCA Mutation Testing — Identifying Risk for Hereditary Breast and Ovarian Cancer

Compared to the general population, patients with a confirmed BRCA mutation have a significantly increased risk of developing cancer during their lifetime - up to an 85% risk of breast cancer, up to a 40% risk of ovarian cancer, and... Read more 

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Chronic Myelogenous Leukemia: Testing to Detect and Treat Imatinib Resistance

The introduction of imatinib (Gleevec®) in 2001 dramatically improved the prognosis of patients with Chronic Myelogenous Leukemia (CML). An important aspect of therapy is the regular monitoring of patient response to identify those patients who are resistant, or become resistant,... Read more 

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Big Data Analytics in Healthcare – How Laboratories Can Play a Leading Role

The capture and analysis of big data offers considerable potential to improve the quality of healthcare and gain insights into public health. Dr. Harvey Kaufman, Senior Medical Director, Quest Diagnostics, discusses this potential, and the important role laboratories can play... Read more 

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Vitamin D and Its Benefits Beyond Bone Health

The role of vitamin D in relation to bone health has been well established. There is also increasing evidence suggesting an association between vitamin D and a wide range of other health conditions, including cardiovascular disease, cancer and infectious disease.... Read more 

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Developmental Delay: Genetic Testing’s Role to Help Guide Diagnosis and Treatment

Causes of developmental delay are typically identified by a combination of observation, physical examination, assessment of family history and a range of diagnostic tests. For disorders of uncertain etiology, chromosomal microarray (CMA) testing provides clinicians with an additional diagnostic tool,... Read more 

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Ion Mobility: Question and Answer Session with the Experts

Question: What is the relationship between lipid regions separated by Ion Mobility and those on traditional gradient gel electrophoresis? Robert Superko, MD: Well, let me ask Ron to comment because he's the individual who developed both of those techniques. Ronald... Read more 

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Advanced Lipid Testing: Enabling a More Accurate Assessment of Cardiovascular Disease Risk

Cardiovascular disease (CVD) is the leading cause of death for both men and women in the U.S. accounting for one in three (approximately 800,000) deaths each year.1 Strategies to reduce the burden of CVD focus on the three leading risk... Read more 

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Personalized Medicine — How Genetics and Genomics are Transforming Healthcare

Personalized medicine has gained much attention following the announcement of a national initiative to fund "a new model of patient-powered research…to accelerate biomedical discoveries and provide clinicians with new tools, knowledge, and therapies to select which treatments will work best... Read more 

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Testosterone Deficiency — Understanding a Complex Condition

Testosterone replacement therapy (TRT) for adult men has increased dramatically in recent years.1, 2 Reflecting an increased awareness among physicians and patients about testosterone deficiency, as well as the impact of an ageing population, this trend has given rise to... Read more 

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Omega-3 Polyunsaturated Fatty Acids

A growing body evidence demonstrates the beneficial effects of Omega-3 Polyunsaturated Fatty Acids (ω-3 PUFA), yet ω-3 PUFA intake among Americans remains well below recommended levels1. Dr. Carl Lavie, Medical Director, Cardiac Rehabilitation and Preventive Cardiology, Ochsner Health System, New... Read more 

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Latent Tuberculosis — Strategies for Early Intervention

About one-third of the world's population has latent tuberculosis (LTBI).1 Those infected with LTBI have a lifetime risk of 10% of developing active TB.1 In the United States it is estimated that there are 10 to 15 million with LTBI.2... Read more 

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HIV Testing — Genotypic Technology in Tropism and Drug Resistance Testing

HIV tropism is defined as the cell type that HIV is able to enter and infect. The identification that HIV frequently uses the CCR5 co-receptor for cell entry led to the introduction of a class of HIV drugs called the... Read more 

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Multistate Fungal Meningitis Outbreak — Guidance For Physicians

The Centers for Disease Control and Prevention (CDC) report that, as of October 22, there have been 304 cases of fungal meningitis and 23 deaths related to epidural injections of a contaminated steroid product.1 Dr. Jay M. Lieberman, Medical Director... Read more 

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Responding Effectively to New and Emerging Infectious Diseases

Throughout history infectious diseases have had a devastating impact on human society.1, 2 New and emerging infectious diseases continue to present a significant public health challenge, testing the medical community's ability to respond to outbreaks rapidly and effectively. Dr. Jay... Read more 

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Prostate Cancer: Current Considerations for Screening and Treatment

Prostate cancer is the second-leading cause of cancer death in men in the United States, accounting for nearly 30,000 deaths per year.1 Incidence of prostate cancer peaked in the early 1990s, corresponding to the increased use of PSA testing for... Read more