Expert Insights Newsletter by Author

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Osteoporosis: Identifying Risk to Reduce the Incidence of Bone Fracture

It is estimated that over 50 million older adults in the United States are affected by osteoporosis or low bone density. Over half of those 50 years or older are affected—10% with osteoporosis and over 40% with low bone mass.1... Read more 

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14-3-3eta (η) Protein — A New Biomarker for Rheumatoid Arthritis

An estimated 1.5 million adults suffer from rheumatoid arthritis in the United States, with the incidence two to three times higher in women than men.1 It is a condition that significantly compromises quality of life, and can increase the risk... Read more 

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A Two-pronged Strategy for Combating Colorectal Cancer

Colorectal cancer a disease that is preventable, treatable and beatable, and for which early detection is of paramount importance. Last year, colorectal cancer (CRC) caused an estimated 51,370 deaths in the U.S1. Most of those deaths could have been prevented.... Read more 

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LDL-C Assessment: A Novel, More Accurate Estimate to Inform Clinical Decision-Making

LDL-C Assessment: A Novel, More Accurate Estimate to Inform Clinical Decision-Making The commonly used value for low-density lipoprotein cholesterol (LDL-C) is not derived from direct measurement, but from an estimate. This estimate can be inaccurate, especially in the setting of... Read more 

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Polycystic Ovary Syndrome (PCOS) and Congenital Adrenal Hyperplasia (CAH) — Meeting the Diagnostic Challenges

PCOS is one of the most common endocrine abnormalities of women, affecting between 5% and 15% of women in their fertile years.1, 2 it has significant clinical features, which may be attributed to other causes if PCOS is not considered... Read more 

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New Trends in Prescription Drug Monitoring

Physicians treating patients with chronic pain face numerous challenges. Pain assessment, therapy selection, patient compliance and drug abuse are all significant issues. Dr Bill McCarberg, Adjunct Assistant Clinical Professor at the University of California, San Diego and Founder of the... Read more 

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Poppy Seeds and the Interpretation of Opiates Drug Testing

The presence of morphine in urine can be due to illicit drug use or poppy seed ingestion, giving rise to the "poppy seed defense" among those receiving a positive drug test result. This presents a challenge for physicians reviewing drug... Read more 

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Pain Medication - The Role of Genetic Variation in Drug Metabolism

Despite the widespread use of pain medications in the United States, there is little understanding among both physicians and patients about the potential variability in response to drugs commonly used for pain management. Dr Leland McClure, Director of Pain Management,... Read more 

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Mass Spectrometry—Applying the Gold Standard in Endocrinology

The availability of mass spectrometry is enabling higher levels of precision and reliability in laboratory diagnostics than has traditionally been possible. Dr. Michael J. McPhaul, Medical Director, Endocrinology and Metabolism, Quest Diagnostics discusses the growing application of mass spectrometry in... Read more 

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Lung Cancer Testing: Why FISH for ALK Testing in NSCLC?

Last year the National Comprehensive Cancer Network (NCCN)1 and the American Society of Clinical Oncology (ASCO)2 issued recommendations for performing gene mutation testing to direct therapy for patients with non-small cell lung carcinoma (NSCLC). Dr. Aurelia Meloni-Ehrig, Chief Director, Cytogenetics,... Read more 

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Cardiovascular Disease — A Comprehensive Approach to Manage the Risks of Cardiac Events

Lowering low-density lipoprotein cholesterol (LDL-C) is the primary target for cardiovascular disease (CVD) risk reduction and can significantly reduce the incidence of cardiovascular (CV) events.1 The latest guidelines, released November 2013, reiterate the need to continue to use evidence-based medicine... Read more 

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Addressing the Dilemma of Prostate Cancer: When to Treat? How to Treat?

Widespread screening for prostate cancer over the last thirty years using the prostate-specific antigen (PSA) test has led to a sharp increase in men being diagnosed with and treated for prostate cancer. Yet recent studies have found that for many... Read more 

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Paraneoplastic Autoantibody Syndromes—Diagnosing Neurological Disorders

Neuronal-specific autoantibodies have a variety of potential targets, and give rise to a range of dysfunctions and neurological syndromes. Diagnosing the associated syndromes can be challenging. Dr. Stanley Naides, Medical Director, Immunology R&D, Quest Diagnostics, discusses the mechanism and presentation... Read more 

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Pediatric Diagnostics

Strategies for a Challenging Field Among the specific challenges of caring for pediatric patients are those related to diagnostic testing, in particular establishing accurate reference ranges (reference intervals) and the need to work with small sample volumes.1, 2 Dr Jon... Read more