Expert Insights Newsletter by Author

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Epilepsy: How Genetic Testing Enables More Precise Diagnosis and Targeted Therapy

About a third of epilepsy patients do not respond to therapy, despite a thorough work-up and extensive testing.1 Genetic testing of these patients can identify specific syndromes and provide a basis for more effective treatment. Dr. Juliann Paolicchi, Professor,Clinical Pediatrics... Read more 

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Epilepsy: How Next-Generation Genetic Testing Can Direct Therapy and Enhance Patient Care

Many types of epilepsy are associated with a genetic mutation, but determining the etiology of certain epilepsies remains a challenge. Dr. Scott Perry, Medical Director, Epilepsy Monitoring Unit, Cook Children's Health Care System, discusses how advances in genetic testing, including... Read more 

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HIV Tropism — Next Generation Genotypic Testing to Predict Virologic Response

The identification of HIV tropism has led to the introduction of a class of HIV drugs, CCR5 coreceptor antagonists, which are effective in patients with the CCR5 coreceptor-using viral variant. An HIV-1 tropism test is required before initiating CCR5 antagonist... Read more 

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Hepatitis C — Recent Advances in Diagnostics and Therapy

Recent advances in diagnosis and treatment are providing physicians with new options for managing patients with chronic HCV. Dr. Rick Pesano, Medical Director, Infectious Diseases, Quest Diagnostics, discusses how these developments can help physicians predict response to therapy and direct... Read more 

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Kidney Stones — Understanding Risk, Reducing Recurrence

Kidney stone disease, also known as nephrolithiasis or urolithiasisis, is one of the most painful and prevalent urological disorders. Each year in the United States, kidney stones account for approximately three million visits to health care providers, and for over... Read more 

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Disaccharidase Deficiency: An Overlooked Digestive Disorder

Disaccharidases are enzymes the break down complex sugars (like lactose) into simple sugars (like glucose) so that the intestine can absorb the nutrients. A deficiency of these enzymes in the duodenum results in a range of gastrointestinal symptoms. The common... Read more 

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Spinal Muscular Atrophy (SMA)

Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, yet public awareness about this devastating disease remains low. Thomas Prior, PhD, Professor of Pathology and Neurology, and Director of Molecular Pathology at The Ohio State University,... Read more 

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Accountable Care Organizations — Transforming Healthcare Delivery

The emergence of Accountable Care Organizations (ACOs) represents a significant shift in the way healthcare is delivered in the United States. John Pritchard, Publisher, ACO Insights, discusses the emergence of ACOs and the promise they hold for reducing cost, increasing... Read more 

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Personalized Medicine in Women’s Health — How Molecular Diagnostics Enables Effective Intervention

Advances in molecular diagnostics have led to a more individualized approach to medicine in different clinical areas. Dr. Douglas Rabin, Medical Director, Women's Health, Quest Diagnostics, reviews the impact of molecular medicine on women's health and discusses how it is... Read more 

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Precision Medicine—An Evolving Role in Oncology

Recent advances in therapeutics and diagnostics are enabling a more targeted approach to treat an increasing number of cancers. Dr. Frederick Racke, Medical Director, Hematology/Oncology and Coagulation,Quest Diagnostics, reviews the evolution of cancer treatment and the increasing role played by... Read more 

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Allergic Disease — The Challenge of Recognition and Diagnosis

50 million people in the United States - 1 in 5 Americans ' suffer from allergy. It is the 5th leading chronic disease in the U.S. and the 3rd most common disease among children under 18 years old of age.1... Read more 

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Hepatitis C — A Review of the CDC Recommendations for Birth-Cohort Screening

The hepatitis C virus (HCV) is a serious public health concern, with an estimated 2.7 ' 3.9 million people living with infection in the United States1, where it is the leading cause of chronic liver disease. The prevalence of HCV... Read more 

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Tuberculosis Remains a Serious Global Health Issue

Saturday, March 24 is World Tuberculosis Day, a day dedicated to raising public awareness that tuberculosis remains a serious global health issue, causing the deaths of several million people each year, and one that is becoming increasingly significant in the... Read more 

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Thyroid Cancer — The Role Of Molecular Testing

Thyroid cancer occurs in 5% to 15% of thyroid nodules detected.1 Accurate diagnosis is therefore essential to avoid unnecessary thyroid surgery for benign disease and to select the most appropriate treatment option for cancerous nodules. Drs. Richard Reitz and Frederic... Read more