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Pain Management Antipsychotics, With Confirmation, Serum and Urine

Test code(s) 94529, 94528

Question 1. What are antipsychotics?

Antipsychotics are medications that can be used to treat mild, moderate, and severe psychosis in patients with schizophrenia and bipolar disorders. These medications can treat thought disorders, hallucinations, and paranoia.

First- and second-generation antipsychotic medications are known as typical and atypical antipsychotics, respectively. Typical and atypical antipsychotics block dopamine D2 receptors in the brain. Atypical antipsychotics also block serotonin 5-hydroxytryptamine receptors.

Examples of typical and atypical antipsychotic drug classes and medications include:

Typical (first generation)

  • Chlorpromazine
  • Fluphenazine
  • Haloperidol
  • Loxapine
  • Mesoridazine
  • Thioridazine
  • Thiothixene
  • Trifluoperazine

Atypical (second generation)

  • Aripiprazole
  • Clozapine
  • Molindone
  • Olanzapine
  • Quetiapine
  • Risperidone
  • Ziprasidone

Question 2. Why test for antipsychotics?

Antipsychotic drug testing can provide information that improves patient care. Test results can often prompt important clinical discussions with patients. For example, the absence of an expected drug could suggest poor adherence or diversion, whereas detection of a nonprescribed licit or illicit drug could raise concerns about substance misuse. Discrepancies between expected and actual results could also call attention to patient intolerance to medication side effects or potential medical factors affecting drug disposition.

Question 3. What are the test codes for the pain management antipsychotic tests?

The test codes are:

Question 4. Where will the tests be performed?

Test codes 94529 and 94528 will be performed at Quest Diagnostics Nichols Institute, Valencia. Additional labs will perform these tests at a later date.

Question 5. What are the characteristics of the pain management antipsychotic tests?

Test Codes 94529 and 94528:
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used for both the presumptive analysis and the definitive quantitative confirmation.

Multiple antipsychotic drugs from both classes are included in the tests. See a list of the drugs and their associated cutoffs.

Question 6. What do the test results mean?

Negative results indicate the absence of drug and/or metabolite or concentrations below the assay cutoff. Positive results indicate the presence of the respective drug and/or metabolite.

Question 7. Can specimens for antipsychotic drug testing be sent in the same bag with other clinical specimens?

Yes. Both the serum and urine drug tests are considered clinical tests; therefore, specimens may be placed in the same specimen bag (specimens of one patient per bag).

Question 8. Whom should a client call with questions about this test?

If you have any questions regarding this information or require assistance with interpreting these drug test results, please contact a Quest Diagnostics toxicology specialist at 1.877.40.RXTOX (1.877.407.9869). Specialists are available to assist you Monday through Friday from 8:00 AM to 6:00 PM EST.

This FAQ is provided for informational purposes only and is not intended as medical advice. A clinician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.
Document FAQS.191 Version: 0
Effective 04/13/2018 to present