Expert Insights Newsletter

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The Genetics of Hearing Loss

Since the sequencing of the human genome, we have made major advances in our understanding of auditory physiology. There have been state-of-the-art developments in the diagnosis of hearing loss, and research continues to advance the use of gene therapy as... Read more 

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Innovations in Alzheimer’s Disease Assessment: Quantitation of Amyloid Beta 40 and 42

Alzheimer's disease (AD) is highly prevalent, and its incidence is expected to double by 2050.1 Understanding the disease through early assessment and differentiating it from other forms of dementia can be helpful for physicians and patients. New approaches to assess... Read more 

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Expanded Carrier Screening: New Guidance on Universal Testing

The American College of Obstetricians and Gynecologists (ACOG) has recently issued an opinion on the use of expanded carrier screening for genetic disorders.1 Lisa Blazejewski, Genetic Counselor, Quest Diagnostics, reviews the rationale for expanded screening and discusses its advantages compared... Read more 

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Autoimmune Neurology—Recent Advances in Disease Identification and Treatment

Autoimmune neurologic diseases are more common than traditionally believed. The recognition of antibodies associated with these conditions has grown significantly over recent years, leading to improvements in diagnosis and treatment. Dr. Steven Vernino, Professor and Vice Chair for Academic Affairs,... Read more 

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LDL-C Assessment: A Novel, More Accurate Estimate to Inform Clinical Decision-Making

LDL-C Assessment: A Novel, More Accurate Estimate to Inform Clinical Decision-Making The commonly used value for low-density lipoprotein cholesterol (LDL-C) is not derived from direct measurement, but from an estimate. This estimate can be inaccurate, especially in the setting of... Read more 

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Osteoporosis: Identifying Risk to Reduce the Incidence of Bone Fracture

It is estimated that over 50 million older adults in the United States are affected by osteoporosis or low bone density. Over half of those 50 years or older are affected—10% with osteoporosis and over 40% with low bone mass.1... Read more 

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Chronic Hepatitis B: The Role of HBsAg Quantitative Testing in Patient Management

In the United States, it is estimated that 850,000 to 2.2 million people are livingwith HBV infection1,2, with many unaware of their infection status.3 Those with chronic HBV infection may have no symptoms of liver disease, or they may have... Read more 

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Precision Medicine—An Evolving Role in Oncology

Recent advances in therapeutics and diagnostics are enabling a more targeted approach to treat an increasing number of cancers. Dr. Frederick Racke, Medical Director, Hematology/Oncology and Coagulation,Quest Diagnostics, reviews the evolution of cancer treatment and the increasing role played by... Read more 

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Paraneoplastic Autoantibody Syndromes—Diagnosing Neurological Disorders

Neuronal-specific autoantibodies have a variety of potential targets, and give rise to a range of dysfunctions and neurological syndromes. Diagnosing the associated syndromes can be challenging. Dr. Stanley Naides, Medical Director, Immunology R&D, Quest Diagnostics, discusses the mechanism and presentation... Read more 

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Polycystic Ovary Syndrome (PCOS)—Making Sense of a Misunderstood Condition

Polycystic Ovary Syndrome (PCOS)—Making Sense of a Misunderstood Condition Polycystic ovary syndrome (PCOS) is a commonly misunderstood condition with a misleading name. Dr. Andrea Dunaif, Charles F. Kettering Professor of Endocrinology and Metabolism, Northwestern University Feinberg School of Medicine, explains... Read more