Difficult Diagnoses in Hematologic Malignancies: Clinical Case Studies Using Genomic Assays
Description: Dan Jones, MD, PhD and Albert Ho, MD, PhD present a series of case studies illustrating the clinical utility of next-generation sequencing and Oligo-SNP arrays to inform the diagnosis of various hematologic malignancies.
Learning objectives — at the conclusion of this program participants will be able to:
• Discuss the role of next-generation sequencing assays in establishing the diagnosis of myeloproliferative neoplasms that don’t have JAK2 or MPL mutations
• Identify diagnostically useful genetic changes in low-grade (cytogenetically normal) myelodysplastic syndromes through use of sequencing panels and genomic arrays
• Describe the use of SNP arrays to supplement conventional karyotyping in the classification of lymphoblastic leukemia and high-grade lymphomas