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Testing a panel of 12 single-nucleotide polymorphims may help identify people at increased risk of atrial fibrillation and stroke, according to a recent study by researchers from the Lund University in Malmö, Sweden, the Broad Institute, Harvard Medical School, Cambridge, MA, and Quest Diagnostics. The award-winning poster may be accessed by ACC attendees through the ACC.14 Attendee Portal.

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Compared to the general population, a woman with a confirmed BRCA1 or BRCA2 mutation is at greater risk of developing cancer during her lifetime—up to an 85% risk of breast cancer and up to a 40% risk of ovarian cancer. Her children, siblings and parents have a 50% chance of having the same autosomal dominant mutation and facing comparable risks.

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Familial Hypercholesterolemia from A to Z

Participants learn about the genetic nature of familiar hypercholesterolemia (FH) including the causal genetic mutations, pathophysiology and how to recognize the typical and atypical features... Read more

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The Clinical Need to Individualize Cardiovascular Diagnosis and Management: Outliers to the Guidelines

Dr. Watson explains the treatment and management of the cardiovascular patient in regards to the 2013 ACC/AHA guidelines, to recognize the gaps and discusses options... Read more

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FISH for Myeloma: What's in a Panel?

Dr. Racke helps participants understand the use of classical cytogenetics, FISH and molecular testing in the diagnosis and risk stratification of plasma cell myeloma and... Read more

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A step toward simplicity for a complex analyte.

Authors: Bystrom CE.Nassar A, Cohen C, Zhou W, Lynch KA, Barker EA, Vanderbilt BL, Thompson J, Heyman ER, Olson A, Lange H, Siddiqui MT.

Clin Chem. 2011;57:1091-1092.


'Criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas, April 2010.

Authors: Pierangeli SS, de Groot PG, Dlott J, Favaloro E, Harris EN, Lakos G, Ortel T, Meroni PL, Otomo K, Pengo V, Tincani A, Wong R, Roubey R.Nassar A, Cohen C, Zhou W, Lynch KA, Barker EA, Vanderbilt BL, Thompson J, Heyman ER, Olson A, Lange H, Siddiqui MT.

Lupus. 2011;20:182-190.


A multisite performance study comparing the reading of immunohistochemical slides on a computer monitor with conventional manual microscopy for estrogen and progesterone receptor analysis.

Quest Diagnostics Authors: Agersborg, S

Authors: Nassar A, Cohen C, Zhou W, Lynch KA, Barker EA, Vanderbilt BL, Thompson J, Heyman ER, Olson A, Lange H, Siddiqui MT.Nassar A, Cohen C, Zhou W, Lynch KA, Barker EA, Vanderbilt BL, Thompson J, Heyman ER, Olson A, Lange H, Siddiqui MT.

Am J Clin Pathol. 2011;135:461-467.


A new immunohistochemical ER/PR image analysis system: a multisite performance study.

Quest Diagnostics Authors: Agersborg, S

Authors: Nassar A, Cohen C, Zhou W, Lynch KA, Heyman ER, Olson A, Lange H, Siddiqui MT.Nassar A, Cohen C, Zhou W, Lynch KA, Barker EA, Vanderbilt BL, Thompson J, Heyman ER, Olson A, Lange H, Siddiqui MT.

Appl Immunohistochem Mol Morphol. 2011;19:195-202.


Age-related differences in patterns of increased Bordetella pertussis antibodies.

Authors: Prince HE, Lieberman JM, Cherry JD.Nassar A, Cohen C, Zhou W, Lynch KA, Barker EA, Vanderbilt BL, Thompson J, Heyman ER, Olson A, Lange H, Siddiqui MT.

Clin Vaccine Immunol. 2012;19:545-550.


Analysis of resistance, cross-resistance and antimicrobial combinations for Pseudomonas aeruginosa isolates from 1997 to 2009.

Authors: Master RN, Clark RB, Karlowsky JA, Ramirez J, Bordon JM.Nassar A, Cohen C, Zhou W, Lynch KA, Barker EA, Vanderbilt BL, Thompson J, Heyman ER, Olson A, Lange H, Siddiqui MT.

Int J Antimicrob Agents. 2011;38:291-295.